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A red blood cell will swell and undergo hemolysis (burst) when placed in a hypotonic solution. When placed in a hypertonic solution, a red blood cell will lose water and undergo crenation (shrivel). In crenation, the cells shrink and their shapes become distorted, often with a ruffled or scalloped edge. Red blood cells are prone to undergoing crenation as either a response to ionic changes in the blood or abnormalities in the cell membrane, disrupting the cell’s ability to maintain an isotonic state.
Instead of the usual rounded biconcave shape, both these cells appear with. Artefactual crenation may be due to slow drying of the smear or aging of blood in the tube. Study sets, textbooks, questions. (a) a red blood cell will undergo crenation, hemolysis, or neither change depending on the osmotic pressure of the solution in which it is placed. If a red blood cell is placed in a hypertonic solution, water leaves the cell, causing it to shrink. When placed in a hypertonic solution, a red blood cell will lose water and undergo crenation (shrivel). A red blood cell will undergo crenation. 0. 1 % (m/v) nacl. A red blood cell will undergo hemolysis.
Red Blood Cell Crenation, Sem Photograph by Steve Gschmeissner
Healthy And Crenated Red Blood Cells, Sem Photograph by Steve Gschmeissner

What Is a Hypertonic Solution?
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Red Blood Cell Crenation, Sem Photograph by Steve Gschmeissner

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